Article
Inadequate response to anti-TNFα therapy is associated with a gain-of-function TNFR2-R polymorphic variant in patients with psoriatic arthritis.
Annals of the rheumatic diseases - 1 Apr 2026
Sullivan James K, Rai Vandana, Harvey Jennifer, Signore Vincent Del, Cheemalavagu Shashank, Lin Jean, Ithychanda Sujay S, Qin Jun, Chandrasekharan Unnikrishnan M, Husni M Elaine
Abstract excerpt
OBJECTIVES: Front-line treatment for psoriatic arthritis (PsA) often involves the use of tumour necrosis factor alpha (TNFα) blocking medications (tumour necrosis factor alpha inhibition [TNFi]). However, more than 40% of patients exhibit inadequate responses, and there is no predictive clinical test available. Our goal is to investigate whether the response to TNFi treatment is associated with TNFα receptor 2...
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