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Article

Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy.

PloS one - 1 Jan 2018

Aita Ada, Basso Daniela, Ramonda Roberta, Moz Stefania, Lorenzin Mariagrazia, Navaglia Filippo, Zambon Carlo-Federico, Padoan Andrea, Plebani Mario, Punzi Leonardo

Abstract excerpt

OBJECTIVES: We investigated whether polymorphisms (SNPs) in the promoter region of TNFA, or in the autoinflammatory TNFRSF1A and MEFV genes, concur with HLA-B27 in enhancing the risk of Spondyloarthritis (SpA) and/or in predicting the response to anti-TNFα treatment. METHODS: 373 controls and 137 SpA (82 with Psoriatic Arthritis-PsA and 55 with Ankylosing Spondylitis- AS; 98/137 under TNFα inhibitor therapy) from...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B27 Antigen

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Spondylitis, Ankylosing

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Source

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Identifiers

PMID: 29579081
DOI: 10.1371/journal.pone.0194693
PMCID: PMC5868803

Genes

MAF
MEFV
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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