Article
Pharmacogenetic analysis of TNF, TNFRSF1A, and TNFRSF1B gene polymorphisms and prediction of response to anti-TNF therapy in psoriasis patients in the Greek population.
Molecular diagnosis & therapy - 1 Feb 2012
Vasilopoulos Yiannis, Manolika Marilena, Zafiriou Efterpi, Sarafidou Theologia, Bagiatis Vasilis, Krüger-Krasagaki Sabine, Tosca Androniki, Patsatsi Aikaterini, Sotiriadis Dimitris, Mamuris Zissis, Roussaki-Schulze Angeliki
Abstract excerpt
BACKGROUND: Although biologic therapies have revolutionized the treatment of psoriasis, patients exhibit a substantial heterogeneous response that could be due to complex genetic heterogeneity. OBJECTIVE: The aim of this study was to investigate the possible influence of tumor necrosis factor-α (TNF), TNF receptor I (TNFRSF1A), and TNF receptor II (TNFRSF1B) gene polymorphisms on anti-TNF treatment responsiveness...
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