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Article

Genome-wide association analysis of psoriasis patients treated with anti-TNF drugs.

Experimental dermatology - 1 Dec 2020

Ovejero-Benito María C, Muñoz-Aceituno Ester, Sabador David, Almoguera Berta, Prieto-Pérez Rocío, Hakonarson Hakon, Coto-Segura Pablo, Carretero Gregorio, Reolid Alejandra, Llamas-Velasco Mar, Abad-Santos Francisco, Daudén Esteban

Abstract excerpt

While anti-TNF therapies are effective against psoriasis, 30%-50% of patients do not show an adequate response to these drugs. Different candidate-gene pharmacogenetics studies have identified single nucleotide polymorphisms that may predict anti-TNF drugs response in psoriasis. Nevertheless, only one paper has undertaken a pharmacogenomic approach failing to find significant biomarkers of biological drug...

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PMID: 33058233
DOI: 10.1111/exd.14215

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