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Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response.

Pharmacogenetics and genomics - 1 May 2010

Potter Catherine, Gibbons Laura J, Bowes John D, Cordell Heather J, Hyrich Kimme, Isaacs John D, Morgan Ann W, Wilson Anthony G, Barton Anne

Abstract excerpt

The introduction of tumour necrosis factor antagonists (anti-TNF) has greatly improved the treatment of rheumatoid arthritis, however, a significant proportion of patients fail to respond to therapy. We hypothesized that variants spanning the type 2 TNF receptor (TNFR2) and the TNF cleavage enzyme (TACE) genes contribute towards the observed variation in patient response (defined as the absolute change in...

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Identifiers

PMID: 20300049
DOI: 10.1097/FPC.0b013e32833878d7

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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