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Article

Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis.

Clinical rheumatology - 1 Jan 2026

Zhou Jianguo, Dou Xiaoyan, Wu Xize, Li Yue, Wang Shixuan, Kang Jian

Abstract excerpt

BACKGROUND: Evidence for the association between rheumatoid arthritis (RA) and osteoporosis (OP) remains inconsistent, and the role of inflammatory cytokines in mediating this association remains unclear. METHODS: This study used linkage disequilibrium score regression (LDSC), Mendelian randomization (MR), and colocalization analyses to assess the association between RA and OP. Mediation MR analysis was conducted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41203929
DOI: 10.1007/s10067-025-07693-5
PMCID: PMC12855326

Genes

FCRL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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