Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rheumatoid arthritis and osteoporosis: shared genetic effect, pleiotropy and causality.

Human molecular genetics - 13 Oct 2021

Yu Xing-Hao, Yang Yi-Qun, Cao Rong-Rong, Cai Mu-Kun, Zhang Lei, Deng Fei-Yan, Lei Shu-Feng

Abstract excerpt

Rheumatoid arthritis (RA) is associated with increased localized and generalized bone loss, but the complex genetic mechanism between them is still unknown. By leveraging large-scale genome-wide association studies summary statistics and individual-level datasets (i.e. UK Biobank), a series of genetic approaches were conducted. Linkage disequilibrium score regression reveals a shared genetic correlation between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Arthritis, Rheumatoid
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Linkage Disequilibrium

Share to Mendelian Randomization Analysis

Share to Osteoporosis

Share to Racial Groups

Source

Identifiers

PMID: 34132789
DOI: 10.1093/hmg/ddab158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rheumatoid arthritis and osteoporosis: shared genetic effect, pleiotropy and causality.PMID 34132789Read ↗

Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways.Semantic proximity Read ↗

Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.Semantic proximity Read ↗

Shared Genetic Architecture Between Rheumatoid Arthritis and Varying Osteoporotic Phenotypes.Semantic proximity Read ↗

Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach.Semantic proximity Read ↗

Insights into the pleiotropic relationships between chronic back pain and inflammation-related musculoskeletal conditions: rheumatoid arthritis and osteoporotic abnormalities.Semantic proximity Read ↗

Potential association of rheumatic diseases with bone mineral density and fractures: a bi-directional mendelian randomization study.Semantic proximity Read ↗

Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis.Semantic proximity Read ↗

Association Between Rheumatoid Arthritis and Osteoporosis in Japanese Populations: A Mendelian Randomization Study.Semantic proximity Read ↗

[Genetic risk factors for rheumatoid arthritis].Semantic proximity Read ↗

Genetics of rheumatoid arthritis contributes to biology and drug discovery.Semantic proximity Read ↗

The genetic puzzle of rheumatoid arthritis: Causes, progression, and treatmentSemantic proximity Read ↗

Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome-Wide Association Study and Inverse Variance-Weighted Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.