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Article

Shared Genetic Architecture Between Rheumatoid Arthritis and Varying Osteoporotic Phenotypes.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2022

Kasher Melody, Freidin Maxim B, Williams Frances Mk, Cherny Stacey S, Malkin Ida, Livshits Gregory

Abstract excerpt

Rheumatoid arthritis (RA) and low bone mineral density (BMD), an indicator of osteoporosis (OP), appear epidemiologically associated. Shared genetic factors may explain this association. This study aimed to investigate the presence of pleiotropy to clarify the potential genetic association between RA and OP. We examined BMDs at varying skeletal sites reported in UK Biobank as well as OP fracture acquired from the...

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PMID: 34910834
DOI: 10.1002/jbmr.4491

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