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Article

Shared genetic architecture and potential comorbid mechanisms between rheumatoid arthritis and idiopathic pulmonary fibrosis.

Clinical rheumatology - 1 Jan 2026

Yuan Minghao, Zhou Yifeng, Long Zhenyi, Peng Yameng, Wu Sixian, Chen Yi, Peng Fang, Zhou Yizhao, Wang Lei, Yuan Hao

Abstract excerpt

OBJECTIVES: Rheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF) commonly coexist, notably in RA-associated interstitial lung disease. Despite clinical overlap, their shared genetic underpinnings remain poorly understood. METHOD: Using large-scale genome-wide association study (GWAS) data from European populations, we assessed genetic correlations between RA and IPF through linkage disequilibrium...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to FOXP3 gene

Share to Genetic Predisposition to Disease

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Share to Idiopathic Pulmonary Fibrosis

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 41174273
DOI: 10.1007/s10067-025-07774-5

Genes

CD4
FOXP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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