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Article

Circulating inflammatory proteins and osteomyelitis: A bidirectional Mendelian randomization and colocalization analysis.

Medicine - 17 Oct 2025

Feng Tianxuan, Chen Peisheng, Lin Fengfei

Abstract excerpt

Circulating inflammatory proteins (CIPs) have been implicated in the progression of osteomyelitis (OM); however, whether these proteins play a causal role or are merely a consequence remains unclear. This study aimed to assess the causal relationships between CIPs and OM using a bidirectional 2-sample Mendelian randomization (MR) approach. MR analyses were performed using genome-wide association study summary...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Osteomyelitis
Genome-Wide Association Study
Osteoprotegerin
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 41189272
DOI: 10.1097/MD.0000000000044916
PMCID: PMC12537171

Genes

TNF
CXCL6
IL10

Provenance

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