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Article

Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways.

Human molecular genetics - 23 Aug 2022

Kasher Melody, Williams Frances M K, Freidin Maxim B, Malkin Ida, Cherny Stacey S, Livshits Gregory

Abstract excerpt

Rheumatoid arthritis (RA) and osteoporosis (OP) are two comorbid complex inflammatory conditions with evidence of shared genetic background and causal relationships. We aimed to clarify the genetic architecture underlying RA and various OP phenotypes while additionally considering an inflammatory component, C-reactive protein (CRP). Genome-wide association study summary statistics were acquired from the GEnetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35349660
DOI: 10.1093/hmg/ddac061
PMCID: PMC9402243

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