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Article

Hepatocyte identity and zonal position determine tumourigenic potential of mutant β-catenin

2023-05-30

Abstract excerpt

<title>Abstract</title> <p> Oncogenic mutations in otherwise normal tissue are common in many adult tissues <sup>1,2</sup> . This suggests multiple events need to converge to drive tumourigenesis and that many processes such as tissue differentiation may be protective against carcinogenesis. Within the liver Wnt/β-catenin signalling maintains zonal differentiation during liver homeostasis <sup>3,4</sup> . Ho...

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Literature Corpus work
33f2ac7d-f7cc-5a9b-86c0-d66040f1ced5
DOI
10.21203/rs.3.rs-2956888/v1
Open publication

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Hepatocyte identity and zonal position determine tumourigenic potential of mutant β-cateninDOI 10.21203/rs.3.rs-2956888/v1
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