Article

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

2026-07-01

Abstract excerpt

Metastatic progression requires cancer cells to adapt to the unique constraints of distant organ microenvironments, yet the mechanisms that drive organ-specific adaptations remain poorly understood. Here, we show that the liver actively rewrites metastatic cancer cell identity, driving tumor cells toward a hepatobiliary progenitor-like state. Through integrated transcriptomic, proteomic, metabolomic, and epigenomi...

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Literature Corpus work: d6f124a9-aff2-5d8c-a5f4-5030ed852168
DOI: 10.64898/2026.06.30.735617

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