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Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy

15 Nov 2017

Abstract excerpt

Methionine adenosyltransferase genes encode enzymes responsible for the biosynthesis of S-adenosylmethionine, the principal biological methyl donor and precursor of polyamines and glutathione. Mammalian cells express three genes - MAT1A, MAT2A, and MAT2B - with distinct expression and functions. MAT1A is mainly expressed in the liver and maintains the differentiated states of both hepatocytes and bile duct...

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PMID: 29141455
DOI: 10.1177/1535370217740860

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