Article
The causal relationship between antihypertensive drugs and knee osteoarthritis: A drug target Mendelian randomization study.
Medicine - 17 Oct 2025
Li Zhixin, Si Yuhao, Liu Mengmin, Tu Pengcheng, Zhang Yafeng, Ma Yong, Guo Yang
Abstract excerpt
Recently studies have revealed a robust association between hypertension and knee osteoarthritis (KOA), with patients likely to suffer from both conditions. We employed Mendelian randomization (MR) analysis to assess the impact of antihypertensive medications on KOA, aiming to offer clinical guidance for concomitant drug therapy and identify potential therapeutic targets for KOA. We obtained exposure instruments...
Read the complete abstract on PubMedTopics
- Humans
- Mendelian Randomization Analysis
- Osteoarthritis, Knee
- Antihypertensive Agents
- Hypertension
- Polymorphism, Single Nucleotide