Article
Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.
Annals of medicine - 1 Dec 2025
Liu Houpu, Zhu Jiahao, Jiang Han, Cai Bingyue, Yang Chen, Sun Lingling, Wang Jing, Li Yingjun
Abstract excerpt
AIMS: The etiology of osteoarthritis (OA) remains unclear, involving a complex interaction of environmental and genetic factors. Observational studies have contributed substantially to identify modifiable risk factors that were associated with OA risk, but conclusions about the causality are hard to draw as these observed associations are susceptible to be interfered with reverse causality and residual...
Read the complete abstract on PubMedTopics
- Humans
- Mendelian Randomization Analysis
- Osteoarthritis
- Risk Factors
- Genetic Predisposition to Disease
- Life Style