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Article

Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2024

Geurts Sven, Tilly Martijn J, Lu Zuolin, Stricker Bruno H C, Deckers Jaap W, de Groot Natasja M S, Miller Clint L, Ikram M Arfan, Kavousi Maryam

Abstract excerpt

BACKGROUND: We investigated the potential impact of antihypertensive drugs for atrial fibrillation (AF) prevention through a drug target Mendelian randomization study to avoid the potential limitations of clinical studies. METHODS: Validated published single-nucleotide polymorphisms (SNPs) that mimic the action of 12 antihypertensive drug classes, including alpha-adrenoceptor blockers, adrenergic neuron blockers,...

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Identifiers

PMID: 39018378
DOI: 10.1161/HYPERTENSIONAHA.123.21858
PMCID: PMC11251507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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