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Article

Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2024

Geurts Sven, Tilly Martijn J, Lu Zuolin, Stricker Bruno H C, Deckers Jaap W, de Groot Natasja M S, Miller Clint L, Ikram M Arfan, Kavousi Maryam

Abstract excerpt

BACKGROUND: We investigated the potential impact of antihypertensive drugs for atrial fibrillation (AF) prevention through a drug target Mendelian randomization study to avoid the potential limitations of clinical studies. METHODS: Validated published single-nucleotide polymorphisms (SNPs) that mimic the action of 12 antihypertensive drug classes, including alpha-adrenoceptor blockers, adrenergic neuron blockers,...

Topics

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Antihypertensive Agents
Atrial Fibrillation
Blood Pressure
Genome-Wide Association Study
Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39018378
DOI: 10.1161/HYPERTENSIONAHA.123.21858
PMCID: PMC11251507

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