Article

Impact of PCSK9 inhibitors on bone disease: A comprehensive drug-target Mendelian randomization study

2025-03-11

Abstract excerpt

<h4>Background</h4> While certain studies suggest a relationship between hyperlipidemia and bone metabolism, the exact nature of proprotein convertase subtilisin/kexin 9 inhibitors (PCSK9i, targeted by, eg, alirocumab), which were originally developed for lowering LDL cholesterol inhibitors, with bone disease is still unclear. This research endeavors to uncover the potential causal relationship between PCSK9i and...

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Literature Corpus work: ef90027b-7c32-5311-96de-ad7d6aa1a35a
DOI: 10.1101/2025.03.09.25323603

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