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Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis

13 Mar 2025

Abstract excerpt

Aims Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors. Despite this, the specific genetic mechanisms underlying OA remain only partially understood, hindering the development of targeted therapeutic strategies. Methods A transcriptome-wide association study (TWAS)...

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PMID: 40079200
DOI: 10.1302/2046-3758.143.bjr-2024-0251.r1

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