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Genetic Links Between Metabolic Syndrome and Osteoarthritis: Insights From Cross-Trait Analysis

13 Mar 2024

Abstract excerpt

CONTEXT: Previous observational studies have indicated a bidirectional association between metabolic syndrome (MetS) and osteoarthritis (OA). However, it remains unclear whether these bidirectional associations reflect causal relationships or shared genetic factors, and the underlying biological mechanisms of this association are not fully understood. OBJECTIVE: We aimed to explore the genetic connection between...

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PMID: 38482593
DOI: 10.1210/clinem/dgae169

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