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Article

Comprehensive computational analysis of PKCδ non-synonymous variants identifies rs1703863535 as a potential breast cancer biomarker.

BMC cancer - 29 Oct 2025

Zafar Sameen, Badshah Yasmin, Shabbir Maria, Khan Somia, Hafeez Amna, Ashraf Naeem Mahmood, Trembley Janeen H, Afsar Tayyaba, Almajwal Ali, Razak Suhail

Abstract excerpt

PKCδ is a key isoform in the PKC subgroup of AGC-kinase proteins, known to be involved in various cellular processes. Dysregulation of its expression has been linked to multiple malignancies. Notably, PKCδ overexpression has been associated with breast cancer progression and poor prognosis. Previous research has shown that PKCδ phosphorylates specific serine residues on target proteins, leading to tumorigenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41162960
DOI: 10.1186/s12885-025-15194-6
PMCID: PMC12570629

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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