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Article

Computational insights into PKCθ non-synonymous SNPs: from structural changes to functional implications.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Hafeez Amna, Farooq Andleeb, Shabbir Maria, Badshah Yasmin, Ashraf Naeem Mahmood, Trembley Janeen H, Afsar Tayyaba, Abusharha Ali, Zafar Sameen, Razak Suhail

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) play a critical role in individual diversity, genome evolution, and susceptibility to diseases such as cancer and diabetes. This study focuses on the PRKCQ gene, encoding protein kinase C theta (PKCθ), a serine/threonine kinase belonging to the PKC family, involved in immune response and cancer progression. Pathogenicity assessment using multiple bioinformatic tools...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40847819
DOI: 10.1080/07391102.2025.2550618

Genes

PRKCQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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