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Article

Theoretical investigation of AKT1 mutations in breast cancer: a computational approach to structural and functional insights.

Journal of computer-aided molecular design - 9 May 2025

Kamaraj Balu, C George Priya Doss

Abstract excerpt

Breast cancer is a complex disease primarily driven by genetic mutations that disrupt crucial signaling pathways, with the AKT1 gene playing a central role in its progression. This study explores the impact of AKT1 mutations using Whole Exome Sequencing (WES), bioinformatics, and computational modeling. Using WES, we identified and prioritized significant mutations in patient samples, specifically D3N, V337M, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40343619
DOI: 10.1007/s10822-025-00601-8

Genes

AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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