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Article

Influence of PRKCE non-synonymous variants on protein dynamics and functionality.

Human molecular genetics - 7 Jul 2022

Khan Khushbukhat, Shah Hania, Rehman Areeba, Badshah Yasmin, Ashraf Naeem M, Shabbir Maria

Abstract excerpt

Novel protein kinase C (nPKC) family member, protein kinase C epsilon (PKCε) is an AGC kinase superfamily member. It is associated with neurological and metabolic diseases as well as human cancers. No study so far has been conducted to identify genetic variations and their effect on PKCε folding and functioning. The present study aimed to identify mutational hotspots in PKCε and disease-causing non-synonymous...

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PMID: 35137073
DOI: 10.1093/hmg/ddac029

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