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Article

Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes.

International journal of molecular sciences - 10 Feb 2017

Petrosino Maria, Lori Laura, Pasquo Alessandra, Lori Clorinda, Consalvi Valerio, Minicozzi Velia, Morante Silvia, Laghezza Antonio, Giorgi Alessandra, Capelli Davide, Chiaraluce Roberta

Abstract excerpt

Genome polymorphisms are responsible for phenotypic differences between humans and for individual susceptibility to genetic diseases and therapeutic responses. Non-synonymous single-nucleotide polymorphisms (nsSNPs) lead to protein variants with a change in the amino acid sequence that may affect the structure and/or function of the protein and may be utilized as efficient structural and functional markers of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28208577
DOI: 10.3390/ijms18020361
PMCID: PMC5343896

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