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Article

Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein.

Scientific reports - 8 Mar 2022

Shah Hania, Khan Khushbukhat, Khan Naila, Badshah Yasmin, Ashraf Naeem Mahmood, Shabbir Maria

Abstract excerpt

Protein kinase C iota (PKCɩ) is a novel protein containing 596 amino acids and is also a member of atypical kinase family. The role of PKCɩ has been explored in neurodegenerative diseases, neuroblastoma, ovarian and pancreatic cancers. Single nucleotide polymorphisms (SNPs) have not been studied in PKCɩ till date. The purpose of the current study is to scrutinize the deleterious missense variants in PKCɩ and...

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Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35260606
DOI: 10.1038/s41598-022-07526-4
PMCID: PMC8904829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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