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Article

Investigating the function of three non-synonymous SNPs in EGFR gene: structural modelling and association with breast cancer.

The protein journal - 1 Jan 2010

Choura Mouna, Frikha Fakher, Kharrat Najla, Aifa Sami, Rebaï Ahmed

Abstract excerpt

Non-synonymous single nucleotide polymorphisms (nsSNPs) represent common genomic variations that alter protein sequence and function. Some nsSNPs affecting conserved amino acids have been reported to be associated with cancer susceptibility. Interestingly, Epidermal Growth Factor Receptor (EGFR) is commonly overexpressed and mutated in many cancers. In this study, we investigated the structural effect of three...

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Source

Identifiers

PMID: 20049516
DOI: 10.1007/s10930-009-9221-0

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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