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Article

Genome-wide identification of loci associated with plasma coagulation factor IX activity.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2026

Han Jihee, Ten Cate Vincent, Li-Gao Ruifang, Robles Alejandro Pallares, Sulochana Harsini Raaja, Andrade-Navarro Miguel A, Ao Linjun, Noordam Raymond, Martinez-Perez Angel, Sabater-Lleal Maria, Soria José Manuel, Souto Juan Carlos, Rosendaal Frits R, Wild Philipp S, van Hylckama Vlieg Astrid

Abstract excerpt

BACKGROUND: Elevated coagulation factor (F) IX activity is associated with an increased risk of cardiovascular diseases, including venous thromboembolism. However, a genome-wide association study for FIX activity remains to be performed. OBJECTIVES: We aimed to identify genetic loci associated with FIX activity. METHODS: We conducted a meta-analysis of genome-wide association studies across 2 population-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41161418
DOI: 10.1016/j.jtha.2025.10.005

Genes

F9
ABO
F12
GCKR
HRG
AHCTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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