Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

doi:10.1093/hmg/ddw401

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Article

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

Human molecular genetics - 1 Feb 2017

Sennblad Bengt, Basu Saonli, Mazur Johanna, Suchon Pierre, Martinez-Perez Angel, van Hylckama Vlieg Astrid, Truong Vinh, Li Yuhuang, Gådin Jesper R, Tang Weihong, Grossman Vera, de Haan Hugoline G, Handin Niklas, Silveira Angela, Souto Juan Carlos, Franco-Cereceda Anders, Morange Pierre-Emmanuel, Gagnon France, Soria Jose Manuel, Eriksson Per, Hamsten Anders, Maegdefessel Lars, Rosendaal Frits R, Wild Philipp, Folsom Aaron R, Trégouët David-Alexandre, Sabater-Lleal Maria

Abstract excerpt

Coagulation factor XI (FXI) has become increasingly interesting for its role in pathogenesis of thrombosis. While elevated plasma levels of FXI have been associated with venous thromboembolism and ischemic stroke, its deficiency is associated with mild bleeding. We aimed to determine novel genetic and post-transcriptional plasma FXI regulators.We performed a genome-wide association study (GWAS) for plasma FXI...

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Identifiers

PMID: 28053049
DOI: 10.1093/hmg/ddw401
PMCID: PMC5703348

Genes

KNG1
GCKR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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