Article
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.
Blood - 2 May 2024
de Vries Paul S, Reventun Paula, Brown Michael R, Heath Adam S, Huffman Jennifer E, Le Ngoc-Quynh, Bebo Allison, Brody Jennifer A, Temprano-Sagrera Gerard, Raffield Laura M, Ozel Ayse Bilge, Thibord Florian, Jain Deepti, Lewis Joshua P, Rodriguez Benjamin A T, Pankratz Nathan, Taylor Kent D, Polasek Ozren, Chen Ming-Huei, Yanek Lisa R, Carrasquilla German D, Marioni Riccardo E, Kleber Marcus E, Trégouët David-Alexandre, Yao Jie, Li-Gao Ruifang, Joshi Peter K, Trompet Stella, Martinez-Perez Angel, Ghanbari Mohsen, Howard Tom E, Reiner Alex P, Arvanitis Marios, Ryan Kathleen A, Bartz Traci M, Rudan Igor, Faraday Nauder, Linneberg Allan, Ekunwe Lynette, Davies Gail, Delgado Graciela E, Suchon Pierre, Guo Xiuqing, Rosendaal Frits R, Klaric Lucija, Noordam Raymond, van Rooij Frank, Curran Joanne E, Wheeler Marsha M, Osburn William O, O'Connell Jeffrey R, Boerwinkle Eric, Beswick Andrew, Psaty Bruce M, Kolcic Ivana, Souto Juan Carlos, Becker Lewis C, Hansen Torben, Doyle Margaret F, Harris Sarah E, Moissl Angela P, Deleuze Jean-François, Rich Stephen S, van Hylckama Vlieg Astrid, Campbell Harry, Stott David J, Soria Jose Manuel, de Maat Moniek P M, Almasy Laura, Brody Lawrence C, Auer Paul L, Mitchell Braxton D, Ben-Shlomo Yoav, Fornage Myriam, Hayward Caroline, Mathias Rasika A, Kilpeläinen Tuomas O, Lange Leslie A, Cox Simon R, März Winfried, Morange Pierre-Emmanuel, Rotter Jerome I, Mook-Kanamori Dennis O, Wilson James F, van der Harst Pim, Jukema J Wouter, Ikram M Arfan, Blangero John, Kooperberg Charles, Desch Karl C, Johnson Andrew D, Sabater-Lleal Maria, Lowenstein Charles J, Smith Nicholas L, Morrison Alanna C
Abstract excerpt
ABSTRACT: Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program along with TOPMed-based imputation of genotypes in additional samples to identify genetic associations with circulating FVIII and VWF levels in a single-variant...
