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Article

A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2012

Sabater-Lleal Maria, Martinez-Perez Angel, Buil Alfonso, Folkersen Lasse, Souto Juan Carlos, Bruzelius Maria, Borrell Montserrat, Odeberg Jacob, Silveira Angela, Eriksson Per, Almasy Laura, Hamsten Anders, Soria José Manuel

Abstract excerpt

OBJECTIVE: Elevated plasma levels of coagulation factor XI (FXI) are implicated in the pathogenesis of venous thromboembolism and ischemic stroke, and polymorphisms in the F11 gene are associated both with risk of venous thromboembolism and an elevated plasma FXI level. METHODS AND RESULTS: Here, we report the first hypothesis-free genome-wide genetic analysis of plasma FXI levels. Two genome-wide significant...

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Source

Identifiers

PMID: 22701019
DOI: 10.1161/ATVBAHA.112.248492

Genes

KNG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time.PMID 22701019Read ↗

Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis.Semantic proximity Read ↗

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.Semantic proximity Read ↗

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Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.Semantic proximity Read ↗

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