Article

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets

2023-12-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Anticoagulants are routinely used by millions of patients worldwide to prevent blood clots. Yet, problems with anticoagulant therapy remain, including a persistent and cumulative bleeding risk in patients undergoing prolonged anticoagulation. New safer anticoagulant targets are needed. <h4>Methods</h4> We performed two-sample Mendelian randomization (MR) and genetic colocaliza...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e6e97b5-3d2d-59e6-9ea9-10de1dfaca8b
DOI: 10.1101/2023.12.05.23299567

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targetsDOI 10.1101/2023.12.05.23299567Read

Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke PreventionSemantic proximity Read

Historical review: more than two decades understanding the genetic architecture of hemostasis and thrombosis.Semantic proximity Read

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.Semantic proximity Read

Coagulation factors and COVID-19 severity: Mendelian randomization analyses and supporting evidenceSemantic proximity Read

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.Semantic proximity Read

Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafishSemantic proximity Read

Genome-wide identification of loci associated with plasma coagulation factor IX activity.Semantic proximity Read

Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis: A Mendelian Randomization Study.Semantic proximity Read

Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study.Semantic proximity Read

Hemostatic phenotypes and genetic disordersSemantic proximity Read

Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood ProteomeSemantic proximity Read

Prediction of Venous Thromboembolism Based on Clinical and Genetic FactorsSemantic proximity Read