Article
Genetic determinants of normal variation in coagulation factor (F) IX levels: genome-wide scan and examination of the FIX structural gene.
Journal of thrombosis and haemostasis : JTH - 1 Jul 2006
Khachidze M, Buil A, Viel K R, Porter S, Warren D, Machiah D K, Soria J M, Souto J C, Ameri A, Lathrop M, Blangero J, Fontcuberta J, Warren S T, Almasy L, Howard T E
Abstract excerpt
BACKGROUND: High-normal and elevated plasma FIX activity (FIX:C) levels are associated with increased risk for venous- and possibly arterial-thrombosis. OBJECTIVE: Because the broad normal range for FIX:C involves a substantial unknown genetic component, we sought to identify quantitative-trait loci (QTLs) for this medically important hemostasis trait. METHODS: We performed a genome-wide screen and a...
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