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Biochemical, molecular and clinical aspects of coagulation factor VII and its role in hemostasis and thrombosis

7 Jan 2021

Abstract excerpt

Activated factor VII (FVIIa), the first protease of clotting, expresses its physiological procoagulant potential only after complexing with tissue factor (TF) exposed to blood. Deep knowledge of the FVIIa-TF complex and F7 gene helps to understand the Janus-faced clinical findings associated to low or elevated FVII activity (FVIIc). Congenital FVII deficiency, the most frequent among the recessively inherited...

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PMID: 33406812
DOI: 10.3324/haematol.2020.248542

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