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Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis

1 Sept 2025

Abstract excerpt

Coagulation factor XII has been identified as a potential drug target that could prevent thrombosis without increasing the risk of bleeding. However, human data to support the development of factor XII-directed therapeutics are lacking. To assess the role of factor XII in venous thromboembolism, we examine genetic variation in the coding region of the F12 locus across 703,745 participants in the UK Biobank and...

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PMID: 40890099
DOI: 10.1038/s41467-025-62789-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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