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Article

Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis.

PloS one - 1 Jan 2017

Martin-Fernandez Laura, Gavidia-Bovadilla Giovana, Corrales Irene, Brunel Helena, Ramírez Lorena, López Sonia, Souto Juan Carlos, Vidal Francisco, Soria José Manuel

Abstract excerpt

Venous thromboembolism is a complex disease with a high heritability. There are significant associations among Factor XI (FXI) levels and SNPs in the KNG1 and F11 loci. Our aim was to identify the genetic variation of KNG1 and F11 that might account for the variability of FXI levels. The KNG1 and F11 loci were sequenced completely in 110 unrelated individuals from the GAIT-2 (Genetic Analysis of Idiopathic...

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Identifiers

PMID: 28445521
DOI: 10.1371/journal.pone.0176301
PMCID: PMC5405990

Genes

KNG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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