The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.

doi:10.1620/tjem.234.143

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.

The Tohoku journal of experimental medicine - 1 Oct 2014

Xu Feng, Sun Yaning, Shang Rui, Li Minghua, Cui Lianqun, Cui Zhaoqiang, Chen Yuguo

Abstract excerpt

Coronary artery disease (CAD) is a leading cause of death, and its genetic mechanism has been always a major research concern. Recently, increasing evidence has indicated that the aldehyde dehydrogenase 2 (ALDH2) polymorphism, known as Glu504Lys (rs671), may contribute to CAD development. ALDH2 has been well known as a key enzyme in alcohol metabolism, and subjects with *504Lys allele exist in 30-50% of the East...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehyde Dehydrogenase, Mitochondrial

Share to Cardiovascular Diseases

Share to Coronary Artery Disease

Share to Glutamic Acid

Share to Lysine

Share to Nitric Oxide Synthase Type III

Share to Oxidative Stress

Source

Open in PubMed

Identifiers

PMID: 25263942
DOI: 10.1620/tjem.234.143

Genes

CAD
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.PMID 25263942Read ↗

Aldehyde dehydrogenase 2-associated metabolic abnormalities and cardiovascular diseases: current status, underlying mechanisms, and clinical recommendationsSemantic proximity Read ↗

Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis.Semantic proximity Read ↗

Impacts of common variants in ALDH2 on coronary artery disease patients.Semantic proximity Read ↗

ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis.Semantic proximity Read ↗

The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu > Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese.Semantic proximity Read ↗

Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome.Semantic proximity Read ↗

Aldehyde dehydrogenase 2 Glu504Lys variant predicts a worse prognosis of acute coronary syndrome patients.Semantic proximity Read ↗

Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis.Semantic proximity Read ↗

Aldehyde Dehydrogenase-2 Roles in Ischemic Cardiovascular Disease.Semantic proximity Read ↗

Advances in Factors Affecting ALDH2 Activity and its Mechanisms.Semantic proximity Read ↗

Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases.Semantic proximity Read ↗

ALDH2 gene G487A polymorphism and coronary artery disease: a meta-analysis including 5644 participants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.