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Article

Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis.

PloS one - 1 Jan 2013

Gleim Scott, Stitham Jeremiah, Tang Wai Ho, Li Hong, Douville Karen, Chelikani Prashen, Rade Jeffrey J, Martin Kathleen A, Hwa John

Abstract excerpt

Thromboxane and its receptor have emerged as key players in modulating vascular thrombotic events. Thus, a dysfunctional hTP genetic variant may protect against (hypoactivity) or promote (hyperactivity) vascular events, based upon its activity on platelets. After extensive in silico analysis, six hTP-α variants were selected (C(68)S, V(80)E, E(94)V, A(160)T, V(176)E, and V(217)I) for detailed biochemical studies...

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Identifiers

PMID: 23840660
DOI: 10.1371/journal.pone.0067314
PMCID: PMC3696120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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