Article
Targeting IDH2R140Q and other neoantigens in acute myeloid leukemia.
Blood - 25 Apr 2024
Leung Wingchi K, Torres Chavez Alejandro G, French-Kim Matthew, Shafer Paul, Mamonkin Maksim, Hill LaQuisa C, Kuvalekar Manik, Velazquez Yovana, Watanabe Ayumi, Watanabe Norihiro, Hoyos Valentina, Lulla Premal, Leen Ann M
Abstract excerpt
ABSTRACT: For patients with high-risk or relapsed/refractory acute myeloid leukemia (AML), allogeneic stem cell transplantation (allo-HSCT) and the graft-versus-leukemia effect mediated by donor T cells, offer the best chance of long-term remission. However, the concurrent transfer of alloreactive T cells can lead to graft-versus-host disease that is associated with transplant-related morbidity and mortality....
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