Article
Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia.
International journal of molecular sciences - 25 Aug 2021
Forghieri Fabio, Riva Giovanni, Lagreca Ivana, Barozzi Patrizia, Bettelli Francesca, Paolini Ambra, Nasillo Vincenzo, Lusenti Beatrice, Pioli Valeria, Giusti Davide, Gilioli Andrea, Colasante Corrado, Galassi Laura, Catellani Hillary, Donatelli Francesca, Talami Annalisa, Maffei Rossana, Martinelli Silvia, Potenza Leonardo, Marasca Roberto, Tagliafico Enrico, Manfredini Rossella, Trenti Tommaso, Comoli Patrizia, Luppi Mario
Abstract excerpt
The C-terminal aminoacidic sequence from NPM1-mutated protein, absent in normal human tissues, may serve as a leukemia-specific antigen and can be considered an ideal target for NPM1-mutated acute myeloid leukemia (AML) immunotherapy. Different in silico instruments and in vitro/ex vivo immunological platforms have identified the most immunogenic epitopes from NPM1-mutated protein. Spontaneous development of...
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