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Article

Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions.

Oncoimmunology - 18 Jan 2021

Shinkawa Tomoyo, Tokita Serina, Nakatsugawa Munehide, Kikuchi Yasuhiro, Kanaseki Takayuki, Torigoe Toshihiko

Abstract excerpt

CD8+ T cells are capable of recognizing mutation-derived neoantigens displayed by HLA class I molecules, thereby exhibiting the ability to distinguish between cancer and normal cells. However, accumulating evidence has shown that only a small fraction of nonsynonymous somatic mutations give rise to clinically relevant neoantigens. The properties of such neoantigens, which must be presented by HLA and immunogenic...

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Identifiers

PMID: 33537174
DOI: 10.1080/2162402X.2020.1870062
PMCID: PMC7833734

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