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Article

Neoantigens in Hematological Malignancies—Ultimate Targets for Immunotherapy?

20 Dec 2019

Abstract excerpt

Neoantigens derive from non-synonymous somatic mutations in malignant cells. Recognition of neoantigens presented via human leukocyte antigen (HLA) molecules on the tumor cell surface by T cells holds promise to enable highly specific and effective anti-cancer immune responses and thus neoantigens provide an exceptionally attractive target for immunotherapy. While genome sequencing approaches already enable the...

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PMID: 31921218
DOI: 10.3389/fimmu.2019.03004

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