Utilizing immunogenomic approaches to prioritize targetable neoantigens for personalized cancer immunotherapy.

Abstract excerpt

Advancements in sequencing technologies and bioinformatics algorithms have expanded our ability to identify tumor-specific somatic mutation-derived antigens (neoantigens). While recent studies have shown neoantigens to be compelling targets for cancer immunotherapy due to their foreign nature and high immunogenicity, the need for increasingly accurate and cost-effective approaches to rapidly identify neoantigens...

Topics

• Humans
• Neoplasms
• Antigens, Neoplasm
• Receptors, Antigen, T-Cell
• Mutation
• Immunotherapy