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A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer

28 Feb 2024

Abstract excerpt

The clinical impact of tumor-specific neoantigens as both immunotherapeutic targets and biomarkers has been impeded by the lack of efficient methods for their identification and validation from routine samples. We have developed a platform that combines bioinformatic analysis of tumor exomes and transcriptional data with functional testing of autologous peripheral blood mononuclear cells (PBMCs) to simultaneously...

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PMID: 38416845
DOI: 10.1126/scitranslmed.abj9905

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