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Article

Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants.

Molecular psychiatry - 1 Mar 2022

Zhang Ruyue, Sjölander Arvid, Ploner Alexander, Lu Donghao, Bulik Cynthia M, Bergen Sarah E

Abstract excerpt

Schizophrenia is a serious mental disorder with considerable somatic and psychiatric morbidity. It is unclear whether comorbid health conditions predominantly arise due to shared genetic risk or consequent to having schizophrenia. To explore the contribution of genetic risk for schizophrenia, we analysed the effect of schizophrenia polygenic risk scores (PRS) on a broad range of health problems in 406 929...

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PMID: 34799693
DOI: 10.1038/s41380-021-01387-5
PMCID: PMC9106855

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