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Article

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts.

Translational psychiatry - 1 Nov 2016

Whalley H C, Adams M J, Hall L S, Clarke T-K, Fernandez-Pujals A M, Gibson J, Wigmore E, Hafferty J, Hagenaars S P, Davies G, Campbell A, Hayward C, Lawrie S M, Porteous D J, Deary I J, McIntosh A M

Abstract excerpt

Major depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of the personality trait neuroticism; factors also associated with schizophrenia (SCZ). It is possible that some cases of MDD may have a substantial genetic loading for SCZ. The presence of SCZ-like MDD subgroups would be indicated by...

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Identifiers

PMID: 27801894
DOI: 10.1038/tp.2016.207
PMCID: PMC5314119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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