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Article

Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and antitumoral activity upon IL-10 or TGFβ stimulation.

Journal for immunotherapy of cancer - 15 Oct 2025

Traxel Sabrina, Schmidt Florian, Beerli Corina, Vuong Dinh-Van, Speck Roberto F, Bredl Simon

Abstract excerpt

BACKGROUND: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that lacks hormone receptors and human epidermal growth factor receptor 2 (HER2) amplification, making it unresponsive to standard hormone or HER2-targeted therapies. Although immune checkpoint inhibitors (ICIs) have shown promise in tumors with high lymphocyte infiltration, their efficacy remains limited in tumors...

Read the complete abstract on PubMed

Topics

Humans
Interleukin-10
Macrophages
Transforming Growth Factor beta
Triple Negative Breast Neoplasms
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Microenvironment

Phenotype

Cell Line, Tumor

STAT1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 41093623
DOI: 10.1136/jitc-2024-011057
PMCID: PMC12530437

Genes

CXCL10
CXCL9
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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