Article

Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and anti-tumoral activity upon IL-10 or TGFβ stimulation

2024-10-03

Abstract excerpt

<h4>Background: </h4> Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that lacks hormone receptors and HER2 amplification, making it unresponsive to standard hormone or HER2-targeted therapies. Although immune checkpoint inhibitors (ICIs) have shown promise in tumors with high lymphocyte infiltration, their efficacy remains limited in tumors with minimal lymphocyte infiltration...

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Literature Corpus work: e909f2b4-a22a-58c9-872c-e5d8af881290
DOI: 10.1101/2024.10.01.615826

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