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Immunotherapeutic IL-6R and Targeting the MCT-1/IL-6/CXCL7/PD-L1 Circuit Prevent Relapse and Metastasis of Triple-Negative Breast Cancer

2023-08-22

Abstract excerpt

<h4>Background: </h4> Multiple copies in T-cell malignancy 1 (MCT-1) is a prognostic biomarker for aggressive breast cancers. Overexpressed MCT-1 stimulates the IL-6/IL-6R/gp130/STAT3 axis, which promotes epithelial-to-mesenchymal transition, cancer stemness and tumor progression. <h4>Methods: </h4> We studied the mechanism underlying triple-negative breast cancer (TNBC) immunity and aggressiveness and assessed pr...

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Literature Corpus work
7b6e009e-f857-5eee-93b1-fc2cf5f133d8
DOI
10.21203/rs.3.rs-3270568/v1
Open publication

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Immunotherapeutic IL-6R and Targeting the MCT-1/IL-6/CXCL7/PD-L1 Circuit Prevent Relapse and Metastasis of Triple-Negative Breast CancerDOI 10.21203/rs.3.rs-3270568/v1
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