Article

CD4+ T-Cells Drive Triple Negative Breast Cancer Recurrence via Non-Canonical TGFβ Signaling

2026-08-17

Abstract excerpt

Radiation therapy is a cornerstone of breast cancer treatment and reduces recurrence overall. However, patients with triple negative breast cancer (TNBC) continue to experience recurrence at higher rates than patients with other subtypes, especially when immunocompromised. While CD8⁺ T-cells are known to mitigate recurrence, the role of CD4+ T-cell subsets in shaping the irradiated microenvironment remains unclear...

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Literature Corpus work: 39647b44-29a4-5da1-a1b9-cc2f79edd9b1
DOI: 10.64898/2026.08.14.744926

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